How does Janna - Savior work when the target is Ruin Runner?

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You still get the heal from Janna - Savior. The “then move an enemy unit from here to its base” portion requires choosing a legal enemy unit; Ruin Runner’s “I can't be chosen by enemy spells and abilities” prevents it from being chosen, so Janna - Savior cannot move Ruin Runner. If no other enemy unit is a legal choice, the move does nothing. A Cleanup occurs after the Move action completes [448] [319].

When you play Janna - Savior at a Battlefield that contains an enemy Ruin Runner, you still resolve the heal portion of Janna - Savior. The subsequent instruction to move “an enemy unit from here to its base” requires choosing a legal enemy unit; Ruin Runner cannot be chosen by enemy spells and abilities, so it is not a legal choice for that instruction. If there is another enemy unit present, you may choose that other unit and move it. If there is no other legal enemy unit, the move step simply does nothing. After the Move action completes, perform a Cleanup [448] [319].

You play Janna - Savior as a Reaction; the card becomes the newest item on the Chain and will resolve in full when it is its turn to resolve [340]. Janna - Savior's text resolves in sequence: first “heal your units here,” then the instruction “move an enemy unit from here to its base.” Executing the card’s game effects in their entirety is handled during resolution [340]. When resolving the move instruction you must choose a legal enemy unit at that Battlefield. Ruin Runner’s ability states it “can't be chosen by enemy spells and abilities,” so it is not a legal choice for an enemy ability attempting to choose an enemy unit (assumption noted). If there is another enemy unit present that is a legal choice, you may choose that unit and move it to its base. If no legal enemy unit exists (e.g., Ruin Runner is the only enemy unit), the move instruction has no legal target and therefore does nothing. After the Move action completes (whether a unit moved or not), perform a Cleanup as required by rule [448], and a Cleanup Outstanding Task is created per [319]. Handle any subsequent Cleanup tasks that apply.

If Janna - Savior is played in response to something else (it’s a Reaction and may be played “even before spells and abilities resolve”), it still resolves in full when it resolves on the Chain; the same target legality rules apply to the move instruction [340]. If an effect changes Ruin Runner’s text (e.g., removes its protection) before Janna - Savior resolves and that change is in effect at the time of resolution, then Ruin Runner could be a legal choice and could be moved. The provided Core Rules excerpt does not include rules about continuous effect timing or dependency, so this follows normal timing assumptions. If any replacement or redirection effect (not present in the provided text) changes or replaces the Move instruction such that no choice is required, the interaction could differ. The Core Rules context provided does not include a replacement rule relevant to this specific scenario, so this possibility is noted but cannot be adjudicated further from the given text.

Resolve Janna - Savior as you would any newest Chain item: execute its full effects in order when it resolves [340]. The card's text instructs two sequential effects: heal your units here, then move an enemy unit from here to its base. The heal portion is applied first and will occur while the ability resolves. The move portion requires selecting a legal enemy unit at that Battlefield as the object of the instruction (this ruling assumes that “move an enemy unit” requires choosing a specific unit). Ruin Runner’s text, “I can't be chosen by enemy spells and abilities,” prevents it from being chosen as part of an enemy spell or ability, so it is not a legal choice for Janna - Savior’s move instruction. Therefore, you cannot choose Ruin Runner to be moved by Janna - Savior. If another enemy unit is present and is a legal choice, you may choose and move that unit instead. If no other legal enemy unit exists, the move portion simply does nothing. After the Move action completes, perform a Cleanup as required by rule [448], and create a Cleanup Outstanding Task per [319].